Subtype of circulating tumor cells with relapse in resected Stage I lung adenocarcinoma

Yanbin Sun

Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, China

Date, time and location: 2018.05.26 17:00, Congress Hall, 2F–C

Abstract

Objectives

More than 20% of lung adenocarcinoma patients develop recurrence, even in the stage I after surgical resection. In the process of recurrence, circulating tumor cells (CTCs) may play a important role. The present study evaluated the influence of CTCs on recurrence in resected stage I lung adenocarcinoma patients. Further, we evaluated the subtype of CTCs on recurrence in the patients.

Methods

Blood samples for CTCs analysis were obtained from 106 patients in pathological stage I adenocarcinoma both before and one month after surgical resection in first hospital of China medical university from 2011-1013. CTCs were isolated with immunomagnetic techniques. Recurrence free survival (RFS) analysis was perfomed.

Results

CTCs were detected in 29.2%(31/106) of patients before surgery and in 14.2%(15/106) one month after surgery. The presence of CTCs(both before surgery and after surgery) was significantly correlated with CEA, pathological subtype, and surgical approach(p<0.05).

25 patients(23.6%) experienced recurrence. The presence of CTCs after surgery was significantly associated with recurrence(p<0.001) and with a shorter RFS, with 3-year RFS rate of 40% compared to 82.4% for CTCs negative group. In multivariate analysis, the presence of CTCs after surgery was an independent factor for the RFS.

Conclusions

The presence of CTCs after radical resection might be an useful marker to predict the recurrence in the early stage lung adenocarcinoma. SUV_max value on preoperative PET scan and CEA were associated with the presence of CTCs after the operation.