Predictors of Paroxysmal Atrial Fibrillation with Patients with the Syndrome of Obstructive Sleep Apnea

Dmitrii Dedov ¹, Dmitrii Dedov  ², Semyon Masjukov ³, Vladimir Mazaev ⁴, Alexandr Ivanov ⁵, Igor Elgardt ⁵, Svetlana Ryazanova ⁴

¹ 1Tver State Medical University, Tver, 2National Medical Research Center of Preventive Medicine, Moscow, 3Regional Clinical Cardiological Dispensary, Tver, Russia, Tver, Russia; ² Tver State Medical University, Tver, Russia; ³ Clinic Expert, Tver, Russia; ⁴ National Medical Research Center of Preventive Medicine, Moscow, Russia; ⁵ Regional Clinical Cardiological Dispensary, Tver, Russia;

Date, time and location: 2018.05.25 13:30, Exhibition area, 1st Floor. Zone – A

Abstract

Objective. To study predictors of paroxysmal atrial fibrillation with patients with the syndrome of obstructive sleep apnea. Methods. 112 patients with the syndrome of obstructive sleep apnea were examined initially and prospectively.They complained of attacks of palpitation during the night. During the observation of paroxysmal atrial fibrillation were registered with 56 patients out of 112 (50,0%) (1^st group: average age 56,4 ± 5,3), 56 patients (50,0%) had no rhythm disturbance (2^nd group: average age 54,7 ± 7,2). Design studies were "case-control". We used standard electrocardiography (ECG) with calculation of maximum, minimum, dispersive (dis), corrected (corr.) P wave, PQ(R) and QT intervals values, Holter ECG monitoring, night pulse oximetry, echocardiography. Analysis was conducted with the help Mann-Whitney U-test, Wilcoxon signed-rank paired difference test, criterion correlation by Spearman (Rs), calculation of sensitivity (Se), specificity (Sp), positive and negative prognostic values (PPV and NPV), chances ratios (CHR). Results. Pdis values with patients in 1^st group were higher by 83,9% than in 2^nd one (p = 0,01). The most predictive value for appearance of rhythm disturbance were demonstrated by Pdis (Se – 66,7%, Sp – 57,9%, PPV – 50,0%, NPV – 26,7%, CHR – 2,7 standard units), and QTcorr. (Se – 54,5%, Sp – 57,1%, PPV – 66,7%, NPV – 55,6%, CHR – 1,6 standard units). Conclusions. Decrease of arterial blood saturation with oxygen during the sleep in 1^st group was associated with increase of Pdis and QTcorr. So, predictors of paroxysmal atrial fibrillation in 1^st group may have the increase of Pdis values and QTcorr.