Long-term Follow-Up of Patients with Esophageal Cancer After Minimally Invasive Esophagectomy (MIE)- NTUH experience of 483 cases

Yu-han Huang, Jang-Ming Lee, Pei-Ming Huang, Pei-Wen Yang, Ke-Cheng Chen

National Taiwan University Hospital, Taipei, Taiwan

Date, time and location: 2018.05.26 17:00, Congress Hall, 2F–C

Abstract

Background

Minimally invasive esophagectomy(MIE) is reported to decrease morbidity and mortality comparing with open esophagectomy. However, studies about long-term survival of MIE is limited. This is our experience in National Taiwan University Hospital(NTUH).

Method(s)

This is a retrospective review of NTUH. Total 483 patients underwentminimally invasive esophagectomy(MIE) in NTUH during 2006/12-2017/04 were enrolled. We followed these patients and observed survival rates. The patients were stratified by pathological stage(stage 0,1,2,3,4), CCRT response(R1,2,3,4), operation method( Ivor Lewis vs. modified McKeown) and lymph node dissection fields( 2 or 3 fields).

Result(s)

Five-year overall survival(OS) after MIE was 48.3%in all 483 patients. The survival time had significant difference in pathological stage(p<0.001), the survival rate in 5 years was 74.2%, 62.3%, 39.4%, 22.0% and 0% for pStage 0,1,2,3,4 patients respectively. No significant difference in operation method(p=0.254) and lymph node dissection fields(p=0.489). Five-year progression-free survival(PFS) was 40.6% in all patients. It also had significant difference in pathological stage(p<0.001) and CCRT response(p<0.001) but no significant difference in operation method(p=0.08) and lymph node dissection fields(p=0.303).

Conclusion

We tried to evaluate the long-term survival rate after MIE. The overall survival and progression-free survival were correlated to pathological stage and CCRT response. Pathological staging and response to CCRT were significant factors influencing long-term survival after surgery.