Effect of Sex Hormones on Early Surgical Outcomes in Fertile Women with Congenital Heart Disease

Haiyun Yuan, Jimei Chen, Xiaobing Liu, Gang Xu, Shusheng Wen, Yanqiu Ou, Zhiqiang Nie, Jian Zhuang

Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangzhou, China

Date, time and location: 2018.05.26 15:30, Exhibition area, 1st Floor. Zone – D

Abstract

Objective: There are no studies directly clarified the effect of sex hormones on early outcomes of cardiac surgery. This study is conducted to investigate this important issues and explore the truth. Methods: We carried out a retrospective, single-center study and enrolled 184 consecutive patients with complex congenital heart diseases (CHD) between Jan. 2010 and Jul. 2015 in Guangdong General Hospital (China). According to the different levels of estrogen or progesterone, patients were divided into high estrogen (>300 pg/ml), middle estrogen (<300 pg/ml and >150 pg/ml) and low estrogen group (<150 pg/ml), or high progesterone (>10 ng/ml) and low progesterone group (<10 ng/ml). Results: Women (n = 184), with mean age of 27.6±5.7 years, were operated and hospitalized for 7(IQR: 6-8) postoperative days. The median intensive care time was 21 (IQR: 18-41) hours, and median normalized amount of chest tube drainage at discharge was 350 (IQR: 243-585) ml. Median postoperative time of using antibiotics was 5 (IQR: 3-6) days, and mean arterial oxygen saturation was 98.3±6.9 %. Mean ejection fraction and haematocrit were 65(IQR: 61-70) % and 32(IQR: 30-35) % respectively. Increased amount of chest tube drainage was observed in high progesterone group and high estrogen group (P < 0.05). However, there was no significance differences in other variables between low progesterone group and high progesterone group, or among low-, middle- and high estrogen groups (P > 0.05). Conclusions: We demonstrated that physiological changes of sex hormone levels had little impact on early surgical outcomes in fertile women with complex CHD. Injection of progesterone for postponing menstruation is a relatively safe and reliable method.